Gene information
Official symbol EPHA2
Official full name EPH receptor A2
Gene type protein-coding gene
Chromosome1p36.13
Previous symbolECK
Gene familySterile alpha motif domain containing; EPH receptors
Resources
Entrez Gene 1969
HGNC HGNC:3386
Ensembl ENSG00000142627
Vega OTTHUMG00000009527
UCSC uc001aya.2
GO terms: 122 records
GO Description Category LogP Number of genes Detail
GO:0000902 cell morphogenesis GO Biological Processes -11.5134430 38 More
GO:0000904 cell morphogenesis involved in differentiation GO Biological Processes -8.70147397 29 More
GO:0001501 skeletal system development GO Biological Processes -17.2073293 69 More
GO:0001525 angiogenesis GO Biological Processes -32.8794581 74 More
GO:0001568 blood vessel development GO Biological Processes -43.2646440 106 More
GO:0001570 vasculogenesis GO Biological Processes -9.47667325 18 More
GO:0001618 virus receptor activity GO Molecular Functions -7.88412825 17 More
GO:0001649 osteoblast differentiation GO Biological Processes -6.81659337 21 More
GO:0001654 eye development GO Biological Processes -3.29977134 15 More
GO:0001704 formation of primary germ layer GO Biological Processes -8.70692533 22 More
GO:0001763 morphogenesis of a branching structure GO Biological Processes -11.2402819 31 More
GO:0001818 negative regulation of cytokine production GO Biological Processes -48.9957481 97 More
GO:0001935 endothelial cell proliferation GO Biological Processes -2.63397233 5 More
GO:0001944 vasculature development GO Biological Processes -42.3240404 107 More
GO:0002009 morphogenesis of an epithelium GO Biological Processes -21.4354199 71 More
GO:0002040 sprouting angiogenesis GO Biological Processes -8.76593708 16 More
GO:0002064 epithelial cell development GO Biological Processes -8.05661081 27 More
GO:0002520 immune system development GO Biological Processes -15.2957169 80 More
GO:0004672 protein kinase activity GO Molecular Functions -2.03527804 36 More
GO:0005911 cell-cell junction GO Cellular Components -3.41801827 38 More
GO:0005925 focal adhesion GO Cellular Components -8.40302345 46 More
GO:0006468 protein phosphorylation GO Biological Processes -5.36604576 56 More
GO:0007167 enzyme-linked receptor protein signaling pathway GO Biological Processes -26.8285253 93 More
GO:0007169 transmembrane receptor protein tyrosine kinase signaling pathway GO Biological Processes -16.7048742 60 More
GO:0007369 gastrulation GO Biological Processes -9.78060849 28 More
GO:0007409 axonogenesis GO Biological Processes -2.66639313 13 More
GO:0007411 axon guidance GO Biological Processes -2.45312404 19 More
GO:0007423 sensory organ development GO Biological Processes -8.10586983 29 More
GO:0008283 cell population proliferation GO Biological Processes -17.2298624 68 More
GO:0008544 epidermis development GO Biological Processes -5.40298147 17 More
GO:0009792 embryo development ending in birth or egg hatching GO Biological Processes -12.9988944 72 More
GO:0009913 epidermal cell differentiation GO Biological Processes -2.68166743 9 More
GO:0010594 regulation of endothelial cell migration GO Biological Processes -41.8778170 72 More
GO:0010632 regulation of epithelial cell migration GO Biological Processes -42.8870194 81 More
GO:0016032 viral process GO Biological Processes -8.84449931 34 More
GO:0016525 negative regulation of angiogenesis GO Biological Processes -31.9326641 51 More
GO:0019058 viral life cycle GO Biological Processes -10.6409496 31 More
GO:0019199 transmembrane receptor protein kinase activity GO Molecular Functions -5.31743835 14 More
GO:0021915 neural tube development GO Biological Processes -7.57225811 24 More
GO:0022612 gland morphogenesis GO Biological Processes -7.35048069 19 More
GO:0030027 lamellipodium GO Cellular Components -1.61995196 15 More
GO:0030055 cell-substrate junction GO Cellular Components -9.04790297 48 More
GO:0030097 hemopoiesis GO Biological Processes -14.1443585 71 More
GO:0030155 regulation of cell adhesion GO Biological Processes -41.8400792 131 More
GO:0030316 osteoclast differentiation GO Biological Processes -2.15842877 6 More
GO:0030335 positive regulation of cell migration GO Biological Processes -66.7331035 139 More
GO:0030855 epithelial cell differentiation GO Biological Processes -14.2408795 69 More
GO:0030879 mammary gland development GO Biological Processes -8.79064244 23 More
GO:0031175 neuron projection development GO Biological Processes -7.36986002 58 More
GO:0031252 cell leading edge GO Cellular Components -1.97716247 28 More
GO:0031344 regulation of cell projection organization GO Biological Processes -8.91314416 62 More
GO:0032642 regulation of chemokine production GO Biological Processes -25.2850711 37 More
GO:0032989 cellular component morphogenesis GO Biological Processes -4.92421328 47 More
GO:0032990 cell part morphogenesis GO Biological Processes -4.32681114 20 More
GO:0033674 positive regulation of kinase activity GO Biological Processes -29.8538991 87 More
GO:0035239 tube morphogenesis GO Biological Processes -44.2569269 123 More
GO:0040017 positive regulation of locomotion GO Biological Processes -69.9490345 147 More
GO:0043009 chordate embryonic development GO Biological Processes -11.8113315 68 More
GO:0043010 camera-type eye development GO Biological Processes -3.41918860 14 More
GO:0043087 regulation of GTPase activity GO Biological Processes -2.19988031 26 More
GO:0043408 regulation of MAPK cascade GO Biological Processes -57.2547066 142 More
GO:0043547 positive regulation of GTPase activity GO Biological Processes -1.94334853 20 More
GO:0043549 regulation of kinase activity GO Biological Processes -36.8507249 123 More
GO:0043588 skin development GO Biological Processes -3.97728448 25 More
GO:0044000 movement in host GO Biological Processes -9.40214314 25 More
GO:0044089 positive regulation of cellular component biogenesis GO Biological Processes -10.7794496 56 More
GO:0045296 cadherin binding GO Molecular Functions -1.90453590 11 More
GO:0045765 regulation of angiogenesis GO Biological Processes -63.6171248 109 More
GO:0046849 bone remodeling GO Biological Processes -4.21089449 9 More
GO:0048514 blood vessel morphogenesis GO Biological Processes -39.8784810 93 More
GO:0048534 hematopoietic or lymphoid organ development GO Biological Processes -16.4041704 79 More
GO:0048562 embryonic organ morphogenesis GO Biological Processes -8.59880895 37 More
GO:0048568 embryonic organ development GO Biological Processes -17.1204114 64 More
GO:0048592 eye morphogenesis GO Biological Processes -1.58766487 12 More
GO:0048593 camera-type eye morphogenesis GO Biological Processes -1.85747522 11 More
GO:0048598 embryonic morphogenesis GO Biological Processes -22.1253699 83 More
GO:0048667 cell morphogenesis involved in neuron differentiation GO Biological Processes -4.77475952 19 More
GO:0048729 tissue morphogenesis GO Biological Processes -31.7796969 96 More
GO:0048732 gland development GO Biological Processes -26.3979320 74 More
GO:0048754 branching morphogenesis of an epithelial tube GO Biological Processes -10.2965313 26 More
GO:0048771 tissue remodeling GO Biological Processes -15.8777137 28 More
GO:0048812 neuron projection morphogenesis GO Biological Processes -4.67859800 20 More
GO:0048858 cell projection morphogenesis GO Biological Processes -4.57120185 20 More
GO:0048880 sensory system development GO Biological Processes -3.47450215 31 More
GO:0050839 cell adhesion molecule binding GO Molecular Functions -14.4506551 68 More
GO:0051272 positive regulation of cellular component movement GO Biological Processes -66.5150412 143 More
GO:0051345 positive regulation of hydrolase activity GO Biological Processes -19.7369783 79 More
GO:0051347 positive regulation of transferase activity GO Biological Processes -26.6059528 90 More
GO:0051701 biological process involved in interaction with host GO Biological Processes -10.6054189 28 More
GO:0051896 regulation of protein kinase B signaling GO Biological Processes -30.5149255 55 More
GO:0060341 regulation of cellular localization GO Biological Processes -10.5933083 72 More
GO:0060443 mammary gland morphogenesis GO Biological Processes -4.29648227 9 More
GO:0060444 branching involved in mammary gland duct morphogenesis GO Biological Processes -2.72529058 5 More
GO:0060491 regulation of cell projection assembly GO Biological Processes -2.36338574 17 More
GO:0060562 epithelial tube morphogenesis GO Biological Processes -17.7630248 53 More
GO:0061138 morphogenesis of a branching epithelium GO Biological Processes -11.1441029 30 More
GO:0061180 mammary gland epithelium development GO Biological Processes -3.92752553 10 More
GO:0061564 axon development GO Biological Processes -3.13387450 15 More
GO:0070160 tight junction GO Cellular Components -1.82849075 6 More
GO:0070372 regulation of ERK1 and ERK2 cascade GO Biological Processes -38.4320790 79 More
GO:0070848 response to growth factor GO Biological Processes -40.6139195 102 More
GO:0072659 protein localization to plasma membrane GO Biological Processes -1.54753800 7 More
GO:0090596 sensory organ morphogenesis GO Biological Processes -4.94155170 15 More
GO:0097485 neuron projection guidance GO Biological Processes -2.79075716 20 More
GO:0120032 regulation of plasma membrane bounded cell projection assembly GO Biological Processes -2.40785708 17 More
GO:0120035 regulation of plasma membrane bounded cell projection organization GO Biological Processes -8.54789693 60 More
GO:0120039 plasma membrane bounded cell projection morphogenesis GO Biological Processes -4.62455556 20 More
GO:0140272 exogenous protein binding GO Molecular Functions -8.63789613 18 More
GO:0150063 visual system development GO Biological Processes -3.59465978 31 More
GO:1901342 regulation of vasculature development GO Biological Processes -64.8504074 111 More
GO:1901343 negative regulation of vasculature development GO Biological Processes -32.5354692 52 More
GO:1901888 regulation of cell junction assembly GO Biological Processes -8.71146171 30 More
GO:1901890 positive regulation of cell junction assembly GO Biological Processes -5.75086352 17 More
GO:1902532 negative regulation of intracellular signal transduction GO Biological Processes -29.4927428 92 More
GO:1903078 positive regulation of protein localization to plasma membrane GO Biological Processes -2.45650021 8 More
GO:1903829 positive regulation of protein localization GO Biological Processes -12.9651258 57 More
GO:1904377 positive regulation of protein localization to cell periphery GO Biological Processes -2.16161219 8 More
GO:1905475 regulation of protein localization to membrane GO Biological Processes -3.01117711 17 More
GO:1905477 positive regulation of protein localization to membrane GO Biological Processes -1.94173448 10 More
GO:1990778 protein localization to cell periphery GO Biological Processes -1.65046880 8 More
GO:2000147 positive regulation of cell motility GO Biological Processes -67.8620360 143 More
GO:2000181 negative regulation of blood vessel morphogenesis GO Biological Processes -32.6997315 52 More
KEGG pathways: 3 records
KEGG Description Category LogP Number of genes Detail
hsa04014 Ras signaling pathway KEGG Pathway -9.01898803 33 More
hsa04151 PI3K-Akt signaling pathway KEGG Pathway -29.3006421 73 More
hsa04360 Axon guidance KEGG Pathway -1.69032736 7 More
Drug-Gene interaction
view
Related drugs: 17 records
Drug name Interaction type Source PMID View
alisertib DTC view
chembl578061 DTC view
cyc-116 DTC view
dasatinib inhibitorantagonist DTCTdgClinicalTrialChemblInteractionsTENDDoCMMyCancerGenomeClinicalTrial 19010823198619602036061020072833180476741713928417016423 view
ilorasertib DTC view
linifanib DTC view
lithoglycocholate DTC 23489211 view
mln-8054 DTC view
osi-632 DTC view
pf-00562271 DTC view
r-406 DTC view
regorafenib inhibitor MyCancerGenomeClinicalTrial view
rg-1530 DTC view
sns-314 DTC view
sorafenib DTC view
tozasertib DTC view
vandetanib inhibitor ChemblInteractions view
Related study: 1 record
Molecular factor Omics type Application Objective MI type Reference
cg08137080 hypermethylation epigenomics myocardial infarction[diagnosis] myocardial infarction Rask-Andersen M et al. Hum Mol Genet. 2016
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